Rheumatoid Profile

A simple rheumatoid profile blood test can can provide important information about rheumatologic conditions, which are marked by inflammation in the joints, muscles, connective tissues, and other structures.

This blood test is commonly performed to detect or evaluate rheumatologic disorders, including systemic lupus erythematosus (SLE), scleroderma, blood vessel inflammation (vasculitis) and types of arthritis (osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout and ankylosing spondylitis).

Although blood tests cannot give a firm rheumatoid arthritis diagnosis, they can help doctors and specialist rheumatologists narrow down clues in the blood about arthritis and inflammation.

Blood markers used to diagnose rheumatoid arthritis:

Rheumatoid factors are a variety of antibodies that are present in seventy to ninety percent of people with  rheumatoid arthritis (RA). However a low level of rheumatoid factor can be found in people without rheumatoid arthritis or with other autoimmune disorders. In general, when no rheumatoid factor is present in someone with rheumatoid arthritis, the course of the disease is less severe. A new test for rheumatoid arthritis, which measures levels of antibodies that bind citrulline modified proteins (anti-CCP), is more specific and tends to be only elevated in patients with rheumatoid arthritis or in patients about to develop rheumatoid arthritis. The presence of anti-CCP antibodies can be used to predict which patients will get more severe rheumatoid arthritis.

Blood markers to determine the presence of inflammation:

The erythrocyte sedimentation rate (ESR) is an indication of the degree of inflammation in the body. It is actually a measurement of the speed with which red blood cells fall in a test tube of blood. When the inflammation in the blood goes up, these inflammatory substances attach to red blood cells and the cells fall faster. In healthy persons the ESR is low, but increases with inflammation. It doesn’t point to any particular disease, but is a general indication of the amount of inflammation in the body. In lupus and  polymyalgia rheumatica, the ESR often correlates with disease activity.

C-reactive protein (CRP) also indicates the amount of inflammation present. In patients with rheumatoid arthritis, if the CRP is high, it suggests that there is significant inflammation or injury in the body.

Both CRP and ESR levels are used to monitor disease activity and how well someone is responding to treatment.

What does the presence of HLA-B27 indicate?

HLA-B27 is a genetic test. In patients with inflammatory arthritis of the  spine and joints (not  osteoarthritis), a positive HLA-B27 test is associated with the presence of one of a group of diseases called seronegative spondyloarthropathies. This includes diseases such as  ankylosing spondylitis (AS),  psoriatic arthritis and Reiter’s syndrome. HLA-B27 is present in about 90% of people with ankylosing spondylitis, but the gene can also be seen in people with no sign of arthritis or inflammation.

We can refer you for a blood test at Spire St Anthony’s Hospital in Cheam where experienced and dedicated nurses will take a blood sample to be analysed in their modern laboratories. Your blood test result will be sent to your practitioner, usually within 24 to 48 hours.